Abstract
Each of the currently known eight herpes viruses can be associated with skin diseases, and depending on the type, certain lesions are typical. All herpes viruses remain in the host (latency) after acute infection, and can show recurrences despite cellular immune response. The possible diseases vary greatly; the type and severity of the disease depends on the age and immune status of the patient, and whether it is a primary or secondary infection. Trigger factors, such as fever, sunlight, trauma, or stress are possible causes of recurrences; the herpes simplex virus is a case in point. Various antivirals are available for treatment, and additional active substances have recently been developed, although these have not been licensed yet.
References
Agut H, Bonnafous P, Gautheret-Dejean A (2015) Laboratory and clinical aspects of human herpesvirus 6 infections. Clin Microbiol Rev 28:313–335
Ahn KH, Park YJ, Hong SC, Lee EH, Lee JS, Oh MJ, Kim HJ (2016) Congenital varicella syndrome: a systematic review. J Obstet Gynaecol 36:563–566
Benedetti JK, Zeh J, Corey L (1999) Clinical reactivation of genital herpes simplex virus infection decreases in frequency over time. Ann Intern Med 131:14–20
Bhatta AK, Keyal U, Liu Y et al (2018) Vertikale Übertragung des Herpes-simplex-Virus: eine Aktualisierung. J Dtsch Dermatol Ges 16:685–693
Bollaerts K, Riera-Montes M, Heininger U et al (2017) A systematic review of varicella seroprevalence in European countries before universal childhood immunization: deriving incidence from seroprevalence data. Epidemiol Infect 145:2666–2677
Brown ZA, Selke S, Zeh J et al (1997) The acquisition of herpes simplex virus during pregnancy. N Engl J Med 337:509–515
Casto AM, Roychoudhury P, Xie H et al (2019) Large, stable, contemporary interspecies recombination events in circulating human herpes simplex viruses. J Infect Dis. epub ahead of print
Cernik C, Gallina K, Brodell RT (2008) The treatment of herpes simplex infections: an evidence-based review. Arch Intern Med 168:1137–1144
Chi CC, Wang SH, Delamere FM et al (2015) Interventions for prevention of herpes simplex labialis (cold sores on the lips). Cochrane Database Syst Rev:CD010095
Corey L, Wald A, Patel R, Sacks SL et al (2004) Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med 350:11–20
Drago F, Broccolo F, Rebora A (2009) Pityriasis rosea: an update with a critical appraisal of its possible herpesviral etiology. J Am Acad Dermatol 61:303–318
Durukan D, Fairley CK, Bradshaw CS et al (2018) Increasing proportion of herpes simplex virus type 1 among women and men diagnosed with first-episode anogenital herpes: a retrospective observational study over 14 years in Melbourne, Australia. Sex Transm Infect 95:307–313
Ebell MH, Call M, Shinholser J, Gardner J (2016) Does this patient have infectious mononucleosis?: the rational clinical examination systematic review. JAMA 315:1502–1509
El Hayderi L, Rübben A, Nikkels AF (2017) Alpha-Herpesviridae in der Dermatologie: Varizella-Zoster-Virus. Hautarzt 68:187–191
El Hayderi L, Rübben A, Nikkels AF (2017) Alpha-Herpesviridae in der Dermatologie: Herpes-Simplex-Virus Typ I und II. Hautarzt 68:181–186
Fatahzadeh M, Schwartz RA (2007) Human herpes simplex virus infections: epidemiology, pathogenesis, symptomatology, diagnosis, and management. J Am Acad Dermatol 57:737–763
Forbes HJ, Williamson E, Benjamin L et al (2018) Association of herpesviruses and stroke: systematic review and meta-analysis. PLoS One 13:e0206163
Gupta R, Warren T, Wald A (2007) Genital herpes. Lancet 370:2127–2137
Heininger U, Seward JF (2006) Varicella. Lancet 368:1365–1376
Hocqueloux L, Guinard J, Buret J et al (2013) Do penicillins really increase the frequency of a rash when given during Epstein-Barr Virus primary infection? Clin Infect Dis 57:1661–1662
Hofstetter AM, Rosenthal SL, Stanberry LR (2014) Current thinking on genital herpes. Curr Opin Infect Dis 27:75–83
Hollier LM, Wendel GD (2008) Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection. Cochrane Database Syst Rev:CD004946
Hurt C, Tammaro D (2007) Diagnostic evaluation of mononucleosis-like illnesses. Am J Med 120:911–918
Hyde TB, Schmid DS, Cannon MJ (2010) Cytomegalovirus seroconversion rates and risk factors: implications for congenital CMV. Rev Med Virol 20:311–326
Itzhaki RF (2018) Corroboration of a major role for herpes simplex virus type 1 in Alzheimer’s disease. Front Aging Neurosci 10:324
Johnston C, Corey L (2016) Current concepts for genital herpes simplex virus infection: diagnostics and pathogenesis of genital tract shedding. Clin Microbiol Rev 29:149–161
Kennedy PGE, Gershon AA (2018) Clinical features of varicella-zoster virus infection. Viruses 10. epub ahead of print
Khadr L, Harfouche M, Omori R et al (2019) The epidemiology of herpes simplex virus type 1 in Asia: systematic review, meta-analyses, and meta-regressions. Clin Infect Dis 68:757–772
Kimberlin DW (2007) Herpes simplex virus infections of the newborn. Semin Perinatol 31:19–25
Kimberlin DW, Whitley RJ (2007) Varicella-zoster vaccine for the prevention of herpes zoster. N English J Med 356:1338–1343
Lal H, Cunningham AL, Godeaux O et al (2015) Efficacy of an adjuvant herpes zoster subunit vaccine in older adults. N Engl J Med 372:2087–2096
Langenberg AG, Corey L, Ashley RL et al (1999) A prospective study of new infections with herpes simplex virus type 1 and type 2. Chiron HSV Vaccine Study Group. N Eng J Med 341:1432–1438
Lautenschlager S, Eichmann A (2001) The heterogeneous clinical spectrum of genital herpes. Dermatology 202:211–219
Lautenschlager S, Eichmann A (2002) Urethritis: an underestimated clinical variant of genital herpes in men? J Am Acad Dermatol 46:307–308
Lebrun-Vignes B, Bouzamondo A, Dupuy A et al (2007) A meta-analysis to assess the efficacy of oral antiviral treatment to prevent genital herpes outbreaks. J Am Acad Dermatol 57:238–246
Looker KJ, Magaret AS, May MT et al (2015) Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PLoS One 10:e0140765
Looker KJ, Elmes JAR, Gottlieb SL et al (2017) Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis. Lancet Infect Dis 17:1303–1316
Martin ET, Krantz E, Gottlieb SL et al (2009) A pooled analysis of the effect of condoms in preventing HSV-2 acquisition. Arch Intern Med 169:1233–1240
Muller WJ, Zheng X (2019) Laboratory diagnosis of neonatal herpes simplex virus infections. J Clin Microbiol 57. epub ahead of print
Oxman MN, Levin MJ, Johnson GR, Schmader KE et al (2005) A vaccine to prevent herpes zoster and postherpetic neuralgia in older adults. N Engl J Med 352:2271–2284
Patel R, Stanberry L, Whitley RJ (2007) Review of recent HSV recurrent-infection treatment studies. Herpes 14:23–26
Peterson AR, Nash E, Anderson BJ (2019) Infectious disease in contact sports. Sports Health 11:47–58
Sadaoka T, Mori Y (2018) Vaccine development for varicella-zoster virus. Adv Exp Med Biol 1045:123–142
Sampath A, Maduro G, Schillinger JA (2016) Infant deaths due to herpes simplex virus, congenital syphilis, and HIV in New York City. Pediatrics 137(4). https://doi.org/10.1542/peds.2015-2387
Sangueza-Acosta M, Sandoval-Romero E (2018) Epstein-Barr virus and skin. An Bras Dermatol 93:786–799
Schwartz RA, Micali G, Nasca MR, Scuderi L (2008) Kaposi sarcoma: a continuing conundrum. J Am Acad Dermatol 59:179–206
Shiraki K (2018) Antiviral drugs against alphaherpesvirus. Adv Exp Med Biol 1045:103–122
Soriano V, Romero JD (2018) Rebound in sexually transmitted infections following the success of antiretrovirals for HIV/AIDS. AIDS Rev 20:187–204
Spruance S, Aoki FY, Tyring S et al (2007) Short-course therapy for recurrent genital herpes and herpes labialis. J Fam Pract 56:30–36
Weinberg JM (2007) Herpes zoster: epidemiology, natural history, and common complications. J Am Acad Dermatol 57:S130–S135
Werner RN, Nikkels AF, Marinovic B et al (2017) European consensus-based (S2k) Guideline on the Management of Herpes Zoster – guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV), Part 1: diagnosis. J Eur Acad Dermatol Venereol 31:9–19
Wollenberg A, Zoch C, Wetzel S et al (2003) Predisposing factors and clinical features of eczema herpeticum: a retrospective analysis of 100 cases. J Am Acad Dermatol 49:198–205
Wolz MM, Sciallis GF, Pittelkow MR (2012) Human herpesviruses 6, 7, and 8 from a dermatologic perspective. Mayo Clin Proc 87:1004–1014
Wu PH, Chuang YS, Lin YT (2019) Does herpes zoster increase the risk of stroke and myocardial infarction? A Comprehensive Review. J Clin Med 8. epub ahead of print
First Describer
Fessler A, Feyrter F (1926) Untersuchungen über das Aphthoid-Pospischill. Z Kinderheilk 41:489–498
Heubner O (1911) Lehrbuch der Kinderheilkunde. Barth, Leipzig, p 445
Hunt JR (1907) On herpetic inflammations of the geniculate ganglion. A new syndrome and its complications. J Nerv Ment Dis 34:73–99
Juliusberg F (1898) Pustulosis acuta varioliformis. Arch Dermatol Syph 49:21–28
Kaposi M (1887) Pathologie und Therapie der Hautkrankheiten. Urban & Schwarzenberg, Wien, p 483
Lipschütz BC (1918) Über Ulcus vulvae acutum. Wien Klin Wochenschr 31:461–464
Pfeiffer E (1889) Drüsenfieber. Jahrb Kinderheilkd Physische Erzieh 29:257–294
Pospischill D (1921) Über Klinik und Epidemiologie der Pertussis. Karger, Berlin
Reye RDK, Morgan G, Baral J (1963) Encephalopathy and fatty degeneration of the viscera: a disease entity in childhood. Lancet 2:749–752
Tzanck A (1947) Le cyto-diagnostic immediate en dermatologie. Ann Dermatol Venereol 7:68–70
Wolf R, Brenner S, Ruocco V et al (1995) Isotopic response. Int J Dermatol 34:341–348
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Lautenschlager, S. (2020). Human Herpes Viruses. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58713-3_9-1
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